The HbS-associated alleles include nonsynonymous variants in the acyl-CoA synthetase family member 2–4 PfACS8 on chromosome 2, in a second region of chromosome 2, and in a region containing structural variation on chromosome 11. We identified a strong association between sickle haemoglobin (HbS) in the host and three regions of the parasite genome, that is not explained by population structure or other covariates, and that is replicated in additional samples. In this study we searched for association between candidate host and parasite genetic variants in 3,346 Gambian and Kenyan children ascertained with severe malaria due to Plasmodium falciparum. Host genetic factors can confer resistance against malaria 1, raising the question of whether this has led to evolutionary adaptation of parasite populations. Malaria protection due to sickle haemoglobin depends on parasite genotype
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |